Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

grouping enzymes into free-floating, multienzyme complexes
All of these
concentrating enzymes within specific cellular compartments
fixing enzymes into membranes so that they are adjacent to each other

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the three-dimensional shape of the molecule
oxidizing the molecules by removing electrons
the input of a small amount of activation energy
changing the reaction from a biosynthetic to a catabolic pathway

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