Enzymes
Common feature in all serine proteases is a

hydrophilic specificity pocket
cluster of reactive serine residues
hydrophobic specificity pocket
single reactive serine residue

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Enzymes
In the enzyme-catalyzed reaction shown below, what will be the effect on substances A, B, C, and D of inactivating the enzyme labeled E2? A ---(E1)---> B ---(E2)---> C ---(E3)--->

A and B will still be produced, but not C or D
A, B, and C will still be produced, but not D
A will still be produced, but not B, C, or D
A, B, C, and D will all still be produced

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

retard the reduction of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

size, shape, and charge of the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
absence of water in the active site

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Enzymes
How is the enzyme COX-1 important in human health?

It helps to transport carbon dioxide in the blood
It is critical for the biosynthesis of DNA
It catalyzes the production of hormones that maintain the stomach lining
It is a chemical derivative of aspirin

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