Enzymes
Common feature in all serine proteases is a

hydrophilic specificity pocket
single reactive serine residue
hydrophobic specificity pocket
cluster of reactive serine residues

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
absence of water in the active site
presence of a low-barrier hydrogen bond in the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

fixing enzymes into membranes so that they are adjacent to each other
All of these
concentrating enzymes within specific cellular compartments
grouping enzymes into free-floating, multienzyme complexes

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