Enzymes
Common feature in all serine proteases is a

hydrophilic specificity pocket
hydrophobic specificity pocket
cluster of reactive serine residues
single reactive serine residue

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Enzymes
In the enzyme-catalyzed reaction shown below, what will be the effect on substances A, B, C, and D of inactivating the enzyme labeled E2? A ---(E1)---> B ---(E2)---> C ---(E3)--->

A, B, and C will still be produced, but not D
A will still be produced, but not B, C, or D
A and B will still be produced, but not C or D
A, B, C, and D will all still be produced

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

size, shape, and charge of the active site or specificity pocket
absence of water in the active site
presence of a low-barrier hydrogen bond in the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket

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