Enzymes
Common feature in all serine proteases is a

single reactive serine residue
cluster of reactive serine residues
hydrophobic specificity pocket
hydrophilic specificity pocket

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both forms an acyl-enzyme intermediate
Both show specificity for certain amino acid sequences
Both use nucleophilic attack to hydrolyze the peptide bond
Both require water to complete the catalytic cycle

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the reaction from a biosynthetic to a catabolic pathway
changing the three-dimensional shape of the molecule
oxidizing the molecules by removing electrons
the input of a small amount of activation energy

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

retard the reduction of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
absence of water in the active site

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