Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

fixing enzymes into membranes so that they are adjacent to each other
concentrating enzymes within specific cellular compartments
All of these
grouping enzymes into free-floating, multienzyme complexes

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