Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
Which of the following statements about enzymes or their function is true?

Enzymes speed up reactions by lowering activation energy
All of these
Enzymes do not alter the overall change in free energy for a reaction
Enzymes are proteins whose three-dimensional form is key to their function

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
absence of water in the active site
size, shape, and charge of the active site or specificity pocket

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both require water to complete the catalytic cycle
Both use nucleophilic attack to hydrolyze the peptide bond
Both show specificity for certain amino acid sequences
Both forms an acyl-enzyme intermediate

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Enzymes
How is the enzyme COX-1 important in human health?

It helps to transport carbon dioxide in the blood
It catalyzes the production of hormones that maintain the stomach lining
It is a chemical derivative of aspirin
It is critical for the biosynthesis of DNA

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