Enzymes
Which of the common features are shared between serine and aspartate proteases?

Both show specificity for certain amino acid sequences
All of these
Both use a base to activate the nucleophile
Both require water to complete the catalytic cycle

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

grouping enzymes into free-floating, multienzyme complexes
fixing enzymes into membranes so that they are adjacent to each other
All of these
concentrating enzymes within specific cellular compartments

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Enzymes
Which of the following statements about enzymes or their function is true?

Enzymes do not alter the overall change in free energy for a reaction
All of these
Enzymes are proteins whose three-dimensional form is key to their function
Enzymes speed up reactions by lowering activation energy

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
absence of water in the active site

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both forms an acyl-enzyme intermediate
Both show specificity for certain amino acid sequences
Both use nucleophilic attack to hydrolyze the peptide bond
Both require water to complete the catalytic cycle

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