Enzymes
Which of the common features are shared between serine and aspartate proteases?

Both use a base to activate the nucleophile
Both require water to complete the catalytic cycle
Both show specificity for certain amino acid sequences
All of these

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the three-dimensional shape of the molecule
oxidizing the molecules by removing electrons
the input of a small amount of activation energy
changing the reaction from a biosynthetic to a catabolic pathway

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

size, shape, and charge of the active site or specificity pocket
absence of water in the active site
proximity of Ser 195 to the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket

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