Enzymes
Which of the common features are shared between serine and aspartate proteases?

Both show specificity for certain amino acid sequences
All of these
Both require water to complete the catalytic cycle
Both use a base to activate the nucleophile

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Enzymes
How is the enzyme COX-1 important in human health?

It is critical for the biosynthesis of DNA
It is a chemical derivative of aspirin
It catalyzes the production of hormones that maintain the stomach lining
It helps to transport carbon dioxide in the blood

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

the input of a small amount of activation energy
oxidizing the molecules by removing electrons
changing the reaction from a biosynthetic to a catabolic pathway
changing the three-dimensional shape of the molecule

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

absence of water in the active site
proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket

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