Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

clamp the substrate into the active site
neutralize the charge on the other's side chain
function as a proton shuttle
keep the specificity pocket open

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Enzymes
How is the enzyme COX-1 important in human health?

It is critical for the biosynthesis of DNA
It helps to transport carbon dioxide in the blood
It catalyzes the production of hormones that maintain the stomach lining
It is a chemical derivative of aspirin

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

presence of a low-barrier hydrogen bond in the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
absence of water in the active site

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