Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

keep the specificity pocket open
neutralize the charge on the other's side chain
clamp the substrate into the active site
function as a proton shuttle

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

size, shape, and charge of the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket
absence of water in the active site

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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