Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

function as a proton shuttle
keep the specificity pocket open
clamp the substrate into the active site
neutralize the charge on the other's side chain

ANSWER DOWNLOAD EXAMIANS APP

Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both require water to complete the catalytic cycle
Both show specificity for certain amino acid sequences
Both use nucleophilic attack to hydrolyze the peptide bond
Both forms an acyl-enzyme intermediate

ANSWER DOWNLOAD EXAMIANS APP

Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket
absence of water in the active site

ANSWER DOWNLOAD EXAMIANS APP

Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

oxidizing the molecules by removing electrons
changing the reaction from a biosynthetic to a catabolic pathway
the input of a small amount of activation energy
changing the three-dimensional shape of the molecule

ANSWER DOWNLOAD EXAMIANS APP

Enzymes
Which of the following statements about enzymes or their function is true?

All of these
Enzymes do not alter the overall change in free energy for a reaction
Enzymes are proteins whose three-dimensional form is key to their function
Enzymes speed up reactions by lowering activation energy

ANSWER DOWNLOAD EXAMIANS APP

Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

concentrating enzymes within specific cellular compartments
fixing enzymes into membranes so that they are adjacent to each other
grouping enzymes into free-floating, multienzyme complexes
All of these

ANSWER DOWNLOAD EXAMIANS APP