Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

keep the specificity pocket open
function as a proton shuttle
clamp the substrate into the active site
neutralize the charge on the other's side chain

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Enzymes
How is the enzyme COX-1 important in human health?

It helps to transport carbon dioxide in the blood
It catalyzes the production of hormones that maintain the stomach lining
It is a chemical derivative of aspirin
It is critical for the biosynthesis of DNA

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

absence of water in the active site
presence of a low-barrier hydrogen bond in the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the reaction from a biosynthetic to a catabolic pathway
oxidizing the molecules by removing electrons
the input of a small amount of activation energy
changing the three-dimensional shape of the molecule

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