Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

neutralize the charge on the other's side chain
function as a proton shuttle
keep the specificity pocket open
clamp the substrate into the active site

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
absence of water in the active site
presence of a low-barrier hydrogen bond in the active site or specificity pocket

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both show specificity for certain amino acid sequences
Both require water to complete the catalytic cycle
Both forms an acyl-enzyme intermediate
Both use nucleophilic attack to hydrolyze the peptide bond

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

All of these
fixing enzymes into membranes so that they are adjacent to each other
grouping enzymes into free-floating, multienzyme complexes
concentrating enzymes within specific cellular compartments

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