Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

keep the specificity pocket open
neutralize the charge on the other's side chain
clamp the substrate into the active site
function as a proton shuttle

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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Enzymes
In the enzyme-catalyzed reaction shown below, what will be the effect on substances A, B, C, and D of inactivating the enzyme labeled E2? A ---(E1)---> B ---(E2)---> C ---(E3)--->

A, B, and C will still be produced, but not D
A, B, C, and D will all still be produced
A will still be produced, but not B, C, or D
A and B will still be produced, but not C or D

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Enzymes
Which of the following statements about enzymes or their function is true?

Enzymes are proteins whose three-dimensional form is key to their function
Enzymes speed up reactions by lowering activation energy
All of these
Enzymes do not alter the overall change in free energy for a reaction

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both show specificity for certain amino acid sequences
Both use nucleophilic attack to hydrolyze the peptide bond
Both forms an acyl-enzyme intermediate
Both require water to complete the catalytic cycle

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Enzymes
How is the enzyme COX-1 important in human health?

It helps to transport carbon dioxide in the blood
It is a chemical derivative of aspirin
It catalyzes the production of hormones that maintain the stomach lining
It is critical for the biosynthesis of DNA

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