Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

keep the specificity pocket open
clamp the substrate into the active site
function as a proton shuttle
neutralize the charge on the other's side chain

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Enzymes
Which of the following statements about enzymes or their function is true?

All of these
Enzymes do not alter the overall change in free energy for a reaction
Enzymes are proteins whose three-dimensional form is key to their function
Enzymes speed up reactions by lowering activation energy

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2

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Enzymes
How is the enzyme COX-1 important in human health?

It is a chemical derivative of aspirin
It catalyzes the production of hormones that maintain the stomach lining
It is critical for the biosynthesis of DNA
It helps to transport carbon dioxide in the blood

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both show specificity for certain amino acid sequences
Both forms an acyl-enzyme intermediate
Both use nucleophilic attack to hydrolyze the peptide bond
Both require water to complete the catalytic cycle

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