Enzymes The role of Asp 102 and His 57 during trypsin catalysis is to function as a proton shuttle keep the specificity pocket open neutralize the charge on the other's side chain clamp the substrate into the active site function as a proton shuttle keep the specificity pocket open neutralize the charge on the other's side chain clamp the substrate into the active site ANSWER DOWNLOAD EXAMIANS APP
Enzymes Which of the common features are shared between serine and aspartate proteases? Both use a base to activate the nucleophile All of these Both show specificity for certain amino acid sequences Both require water to complete the catalytic cycle Both use a base to activate the nucleophile All of these Both show specificity for certain amino acid sequences Both require water to complete the catalytic cycle ANSWER DOWNLOAD EXAMIANS APP
Enzymes Which of the following statements about enzymes or their function is true? All of these Enzymes do not alter the overall change in free energy for a reaction Enzymes speed up reactions by lowering activation energy Enzymes are proteins whose three-dimensional form is key to their function All of these Enzymes do not alter the overall change in free energy for a reaction Enzymes speed up reactions by lowering activation energy Enzymes are proteins whose three-dimensional form is key to their function ANSWER DOWNLOAD EXAMIANS APP
Enzymes The proteolysis rate enhancement by chymotrypsin (~1010 folds) corresponds to a reduction in activation energy of about 88 kJ/mol 49 kJ/mol 58 kJ/mol 40 kJ/mol 88 kJ/mol 49 kJ/mol 58 kJ/mol 40 kJ/mol ANSWER DOWNLOAD EXAMIANS APP
Enzymes The cleavage specificity of trypsin and chymotrypsin depend in part on the presence of a low-barrier hydrogen bond in the active site or specificity pocket absence of water in the active site proximity of Ser 195 to the active site or specificity pocket size, shape, and charge of the active site or specificity pocket presence of a low-barrier hydrogen bond in the active site or specificity pocket absence of water in the active site proximity of Ser 195 to the active site or specificity pocket size, shape, and charge of the active site or specificity pocket ANSWER DOWNLOAD EXAMIANS APP
Enzymes Which of the following is false statement with regard to comparison between Serine and HIV proteases? Both show specificity for certain amino acid sequences Both require water to complete the catalytic cycle Both use nucleophilic attack to hydrolyze the peptide bond Both forms an acyl-enzyme intermediate Both show specificity for certain amino acid sequences Both require water to complete the catalytic cycle Both use nucleophilic attack to hydrolyze the peptide bond Both forms an acyl-enzyme intermediate ANSWER DOWNLOAD EXAMIANS APP
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