Enzymes
The role of Asp 102 and His 57 during trypsin catalysis is to

keep the specificity pocket open
function as a proton shuttle
clamp the substrate into the active site
neutralize the charge on the other's side chain

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

oxidizing the molecules by removing electrons
the input of a small amount of activation energy
changing the reaction from a biosynthetic to a catabolic pathway
changing the three-dimensional shape of the molecule

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both show specificity for certain amino acid sequences
Both forms an acyl-enzyme intermediate
Both use nucleophilic attack to hydrolyze the peptide bond
Both require water to complete the catalytic cycle

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Enzymes
Which of the following statements about enzymes or their function is true?

Enzymes speed up reactions by lowering activation energy
All of these
Enzymes do not alter the overall change in free energy for a reaction
Enzymes are proteins whose three-dimensional form is key to their function

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Enzymes
How is the enzyme COX-1 important in human health?

It is a chemical derivative of aspirin
It helps to transport carbon dioxide in the blood
It is critical for the biosynthesis of DNA
It catalyzes the production of hormones that maintain the stomach lining

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