Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

grouping enzymes into free-floating, multienzyme complexes
All of these
fixing enzymes into membranes so that they are adjacent to each other
concentrating enzymes within specific cellular compartments

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

presence of a low-barrier hydrogen bond in the active site or specificity pocket
absence of water in the active site
size, shape, and charge of the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket

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Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the three-dimensional shape of the molecule
changing the reaction from a biosynthetic to a catabolic pathway
the input of a small amount of activation energy
oxidizing the molecules by removing electrons

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2

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