Recombinant DNA Technology
Which of the following is not true of small inbreeding populations?

Mutation is increased
Alleles may become fixed
There is an increased incidence of recessive diseases
They tend to loose genetic diversity

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Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

short sequences that will hybridize only to a specific base sequence
copies of the gene with an altered sequence so that a restriction site is inserted
PCR-amplified variable numbers of tandem repeats (VNTRs)
mutagenized copies of a gene

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