Microorganisms and Disease
What is common in catheters and ventilators?

They are used primarily in neonatal intensive care units
They bypass important defenses of the body
They predispose patients to viral rather than bacterial infections
Bacteria responsible for associated infections are usually susceptible to antibiotics

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
ADP ribosylation of adenylate cyclase that stops production of cAMP

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