Microorganisms and Disease
Mucus helps in protecting against pathogens by

blocking access and attachment of pathogens to mucosal surfaces
lowering the pH
facilitating the growth of normal flora
sequestering Iron

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Microorganisms and Disease
The influenza vaccine is administered each year because

None of these
it is a polysaccharide vaccine that does not confer long-term protection
mutations in the viral hemagglutinin may allow the virus to evade the immune response elicited by previous vaccines
the vaccine is sufficiently toxic to make it necessary to administer only a small amount at any one time

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of adenylate cyclase that stops production of cAMP
ADP ribosylation of guanylate cyclase that stimulates production of cGMP

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

binds host cell receptors found on heart cells
lysis macrophages with the release of cytokines
cause ADP ribosylation of a factor involved in protein synthesis
forms cAMP that leads to fluid accumulation

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