Microorganisms and Disease
Both Mycobacterium tuberculosis and Streptococcus pneumoniae

have polysaccharide capsules
stay in the lung and rarely, if ever, enter the bloodstream
are acquired by inhalation
have cell walls that contain a high content of mycolic acids

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
ADP ribosylation of adenylate cyclase that stops production of cAMP

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

forms cAMP that leads to fluid accumulation
binds host cell receptors found on heart cells
lysis macrophages with the release of cytokines
cause ADP ribosylation of a factor involved in protein synthesis

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