Microorganisms and Disease
What is common in catheters and ventilators?

They predispose patients to viral rather than bacterial infections
They bypass important defenses of the body
Bacteria responsible for associated infections are usually susceptible to antibiotics
They are used primarily in neonatal intensive care units

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

forms cAMP that leads to fluid accumulation
cause ADP ribosylation of a factor involved in protein synthesis
lysis macrophages with the release of cytokines
binds host cell receptors found on heart cells

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Microorganisms and Disease
Type III secretion systems are used to inject "effector" proteins directly into a host cell. Salmonella uses a type III secretion system to help the pathogen to

survive within macrophages
secrete LT (heat labile toxin) and ST (heat stable toxin) into the lumen of the intestine
survive the acid pH of the stomach
activate T cells to proliferate and secrete cytokines

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