Microorganisms and Disease
The "A" subunit of diphtheria toxin

binds host cell receptors found on heart cells
forms cAMP that leads to fluid accumulation
lysis macrophages with the release of cytokines
cause ADP ribosylation of a factor involved in protein synthesis

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Microorganisms and Disease
What is common in catheters and ventilators?

They are used primarily in neonatal intensive care units
They bypass important defenses of the body
Bacteria responsible for associated infections are usually susceptible to antibiotics
They predispose patients to viral rather than bacterial infections

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