Microorganisms and Disease
The "A" subunit of diphtheria toxin

forms cAMP that leads to fluid accumulation
lysis macrophages with the release of cytokines
cause ADP ribosylation of a factor involved in protein synthesis
binds host cell receptors found on heart cells

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Microorganisms and Disease
Which of the following is common in the disease caused by Coryne-bacterium diphtheriae and Bacillus anthracis?

Diphtheria toxin and edema toxin are ADP ribosylating toxins
Both organisms are gram-positive spore formers
The most serious disease symptoms are the direct result of toxin action
Both organisms cause skin and respiratory tract infections

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Microorganisms and Disease
Type III secretion systems are used to inject "effector" proteins directly into a host cell. Salmonella uses a type III secretion system to help the pathogen to

survive the acid pH of the stomach
secrete LT (heat labile toxin) and ST (heat stable toxin) into the lumen of the intestine
survive within macrophages
activate T cells to proliferate and secrete cytokines

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