Microorganisms and Disease
The "A" subunit of diphtheria toxin

lysis macrophages with the release of cytokines
forms cAMP that leads to fluid accumulation
binds host cell receptors found on heart cells
cause ADP ribosylation of a factor involved in protein synthesis

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
ADP ribosylation of adenylate cyclase that stops production of cAMP
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
cleavage of rRNA that results in disruption of ribosome function

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Microorganisms and Disease
Which of the following characteristic of the Rotavirus was important for the construction of the Rotashield vaccine?

The ability of the Rotavirus to be transmitted faster
The possession of a segmented RNA genome
The ability of monkey Rotavirus strains to cause serious illness (diarrhea) in human beings
A limited number of capsule types

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Microorganisms and Disease
What is common in catheters and ventilators?

Bacteria responsible for associated infections are usually susceptible to antibiotics
They are used primarily in neonatal intensive care units
They bypass important defenses of the body
They predispose patients to viral rather than bacterial infections

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Microorganisms and Disease
Plastic implants can pose a serious nosocomial infection problem because

All of these
infected implants usually have to be surgically removed
phagocytes have trouble moving on the plastic surface
phagocytes have trouble engulfing bacteria embedded in a biofilm

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