Microorganisms and Disease
The "A" subunit of diphtheria toxin

lysis macrophages with the release of cytokines
forms cAMP that leads to fluid accumulation
binds host cell receptors found on heart cells
cause ADP ribosylation of a factor involved in protein synthesis

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Microorganisms and Disease
Which of the following characteristic of the Rotavirus was important for the construction of the Rotashield vaccine?

A limited number of capsule types
The possession of a segmented RNA genome
The ability of the Rotavirus to be transmitted faster
The ability of monkey Rotavirus strains to cause serious illness (diarrhea) in human beings

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Microorganisms and Disease
Which of the following is common in the disease caused by Coryne-bacterium diphtheriae and Bacillus anthracis?

Both organisms cause skin and respiratory tract infections
Diphtheria toxin and edema toxin are ADP ribosylating toxins
The most serious disease symptoms are the direct result of toxin action
Both organisms are gram-positive spore formers

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of guanylate cyclase that stimulates production of cGMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP
ADP ribosylation of adenylate cyclase that stops production of cAMP

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