Cell Signalling and Transduction
The signaling molecules called steroid hormones

never enter the blood of humans
bind to cell surface receptors to trigger chemical cascades
are hydrophilic and so cannot penetrate the plasma membrane
are made in one location of the body but have their effects some distance away

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Cell Signalling and Transduction
Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

makes the receptor more likely to capture the signaling, molecule
changes the shape and thus the enzymatic activity of the proteins involved
allows hydrophilic signaling molecules to cross the plasma membrane
None of these

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