Cell Signalling and Transduction
The signaling molecules called steroid hormones

are hydrophilic and so cannot penetrate the plasma membrane
are made in one location of the body but have their effects some distance away
never enter the blood of humans
bind to cell surface receptors to trigger chemical cascades

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Cell Signalling and Transduction
When a __________ reaches its __________ , there is a specific means of receiving it and acting on the message. This task is the responsibility of specialized proteins called __________ .

signaling molecule; target cell; G proteins
signaling molecule; receptor; G proteins
kinase; receptor; proteases
signaling molecule; target cell; receptors

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Cell Signalling and Transduction
Two key organizing principles for large multicellular organisms are

simple nerve reflexes and cell specialization
prokaryotic cell structure and cell specialization
communication between cells and simple nerve reflexes
cell specialization and communication between cells

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Cell Signalling and Transduction
Nitroglycerin has long been administered to human patients suffering from chronic chest pain (angina). This medication works because it

mimics the action of signal receptors
breaks down into nitric oxide, which increases blood flow to the heart
is broken down into hormones that affect the heart
interferes with chemical cascades that trigger contraction of heart muscle

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Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

increase in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger
increase in the concentration of certain extracellular signaling molecules called first messenger

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