Cell Signalling and Transduction
The signaling molecules called steroid hormones

are hydrophilic and so cannot penetrate the plasma membrane
bind to cell surface receptors to trigger chemical cascades
never enter the blood of humans
are made in one location of the body but have their effects some distance away

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Cell Signalling and Transduction
In the signal transduction mechanism known as protein phosphorylation

All of these
phosphorylated proteins act with enzymes to trigger the signal cascade
the signaling molecule binds to a surface receptor
receptor kinases play a key role in triggering the signal cascade

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Cell Signalling and Transduction
Nitroglycerin has long been administered to human patients suffering from chronic chest pain (angina). This medication works because it

interferes with chemical cascades that trigger contraction of heart muscle
breaks down into nitric oxide, which increases blood flow to the heart
mimics the action of signal receptors
is broken down into hormones that affect the heart

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Cell Signalling and Transduction
A signal cascade induced by adrenaline or thyroxine

must begin with receipt of the signal molecule by a surface receptor
All of these
involves the activation of a G protein
results in the activation of a sequence of enzymes needed for the cell effect

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