Cell Signalling and Transduction
Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

allows hydrophilic signaling molecules to cross the plasma membrane
changes the shape and thus the enzymatic activity of the proteins involved
None of these
makes the receptor more likely to capture the signaling, molecule

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Cell Signalling and Transduction
Two key organizing principles for large multicellular organisms are

simple nerve reflexes and cell specialization
prokaryotic cell structure and cell specialization
cell specialization and communication between cells
communication between cells and simple nerve reflexes

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