Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

decrease in the concentration of certain intracellular signaling molecules called second messenger
increase in the concentration of certain extracellular signaling molecules called first messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger
increase in the concentration of certain intracellular signaling molecules called second messenger

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Cell Signalling and Transduction
The signaling molecules called steroid hormones

are hydrophilic and so cannot penetrate the plasma membrane
are made in one location of the body but have their effects some distance away
bind to cell surface receptors to trigger chemical cascades
never enter the blood of humans

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Cell Signalling and Transduction
Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

changes the shape and thus the enzymatic activity of the proteins involved
allows hydrophilic signaling molecules to cross the plasma membrane
None of these
makes the receptor more likely to capture the signaling, molecule

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Cell Signalling and Transduction
In terms of cell communication, what do bacterial pathogens such as cholera and anthrax have in common?

They destroy the receptors for key signaling molecules
They block the normal functioning of signal transduction mechanisms
They prevent the production of key signaling molecules
They alter the chemical structure of key signaling molecules

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