Cell Signalling and Transduction
Two key organizing principles for large multicellular organisms are

simple nerve reflexes and cell specialization
prokaryotic cell structure and cell specialization
communication between cells and simple nerve reflexes
cell specialization and communication between cells

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Cell Signalling and Transduction
Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

None of these
allows hydrophilic signaling molecules to cross the plasma membrane
makes the receptor more likely to capture the signaling, molecule
changes the shape and thus the enzymatic activity of the proteins involved

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Cell Signalling and Transduction
The signaling molecules called steroid hormones

are hydrophilic and so cannot penetrate the plasma membrane
are made in one location of the body but have their effects some distance away
never enter the blood of humans
bind to cell surface receptors to trigger chemical cascades

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