Cell Signalling and Transduction
The signaling molecules called steroid hormones

are made in one location of the body but have their effects some distance away
never enter the blood of humans
bind to cell surface receptors to trigger chemical cascades
are hydrophilic and so cannot penetrate the plasma membrane

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Cell Signalling and Transduction
In the signal transduction mechanism known as protein phosphorylation

receptor kinases play a key role in triggering the signal cascade
phosphorylated proteins act with enzymes to trigger the signal cascade
the signaling molecule binds to a surface receptor
All of these

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Cell Signalling and Transduction
Self-phosphorylation is an excellent mechanism for triggering specific catalytic function of the proteins involved in signal cascades because it

None of these
makes the receptor more likely to capture the signaling, molecule
allows hydrophilic signaling molecules to cross the plasma membrane
changes the shape and thus the enzymatic activity of the proteins involved

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