Cell Signalling and Transduction
Nitroglycerin has long been administered to human patients suffering from chronic chest pain (angina). This medication works because it

interferes with chemical cascades that trigger contraction of heart muscle
breaks down into nitric oxide, which increases blood flow to the heart
mimics the action of signal receptors
is broken down into hormones that affect the heart

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Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

increase in the concentration of certain extracellular signaling molecules called first messenger
decrease in the concentration of certain intracellular signaling molecules called second messenger
increase in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger

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