Cell Signalling and Transduction
Nitroglycerin has long been administered to human patients suffering from chronic chest pain (angina). This medication works because it

is broken down into hormones that affect the heart
mimics the action of signal receptors
breaks down into nitric oxide, which increases blood flow to the heart
interferes with chemical cascades that trigger contraction of heart muscle

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Cell Signalling and Transduction
A signal cascade induced by adrenaline or thyroxine

results in the activation of a sequence of enzymes needed for the cell effect
involves the activation of a G protein
All of these
must begin with receipt of the signal molecule by a surface receptor

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Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

increase in the concentration of certain extracellular signaling molecules called first messenger
decrease in the concentration of certain intracellular signaling molecules called second messenger
increase in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger

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