Cell Signalling and Transduction
In the signal transduction mechanism known as protein phosphorylation

the signaling molecule binds to a surface receptor
All of these
receptor kinases play a key role in triggering the signal cascade
phosphorylated proteins act with enzymes to trigger the signal cascade

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Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

decrease in the concentration of certain intracellular signaling molecules called second messenger
increase in the concentration of certain extracellular signaling molecules called first messenger
increase in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger

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