Cell Signalling and Transduction
Nitroglycerin has long been administered to human patients suffering from chronic chest pain (angina). This medication works because it

interferes with chemical cascades that trigger contraction of heart muscle
mimics the action of signal receptors
breaks down into nitric oxide, which increases blood flow to the heart
is broken down into hormones that affect the heart

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Cell Signalling and Transduction
The signaling molecules called steroid hormones

are hydrophilic and so cannot penetrate the plasma membrane
bind to cell surface receptors to trigger chemical cascades
never enter the blood of humans
are made in one location of the body but have their effects some distance away

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