Water, pH and Macromolecules
Most of the important functional groups in biological molecules contain

nitrogen and a phosphate
oxygen and a phosphate
oxygen and/or nitrogen and are polar
oxygen and/or nitrogen and are acidic

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Water, pH and Macromolecules
The main difference between an acid and a base is that

bases are polar molecules and acids are not
acids are polar molecules and bases are not
acids donate hydrogen ions in water while bases accept hydrogen ions
bases donate hydrogen ions in water while acids accept hydrogen ions

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