Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

the input of a small amount of activation energy
oxidizing the molecules by removing electrons
changing the three-dimensional shape of the molecule
changing the reaction from a biosynthetic to a catabolic pathway

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

concentrating enzymes within specific cellular compartments
grouping enzymes into free-floating, multienzyme complexes
fixing enzymes into membranes so that they are adjacent to each other
All of these

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both use nucleophilic attack to hydrolyze the peptide bond
Both show specificity for certain amino acid sequences
Both forms an acyl-enzyme intermediate
Both require water to complete the catalytic cycle

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

absence of water in the active site
proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket
presence of a low-barrier hydrogen bond in the active site or specificity pocket

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