Enzymes
Before they can react, many molecules need to be destabilized. This state is typically achieved through

changing the three-dimensional shape of the molecule
the input of a small amount of activation energy
oxidizing the molecules by removing electrons
changing the reaction from a biosynthetic to a catabolic pathway

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Enzymes
Which of the following is false statement with regard to comparison between Serine and HIV proteases?

Both forms an acyl-enzyme intermediate
Both require water to complete the catalytic cycle
Both use nucleophilic attack to hydrolyze the peptide bond
Both show specificity for certain amino acid sequences

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Enzymes
The E.coli pyruvic acid dehydrogenase complex is reported to

decatalyze the oxidation of pyruvic acid to acetyl Co A and CO2
retard the reduction of pyruvic acid to acetyl Co A and CO2
Catalyze the oxidation of pyruvic acid to acetyl Co A and CO2
Catalyze the reduction of pyruvic acid to acetyl Co A and CO2

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Enzymes
In the enzyme-catalyzed reaction shown below, what will be the effect on substances A, B, C, and D of inactivating the enzyme labeled E2? A ---(E1)---> B ---(E2)---> C ---(E3)--->

A, B, C, and D will all still be produced
A, B, and C will still be produced, but not D
A and B will still be produced, but not C or D
A will still be produced, but not B, C, or D

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Enzymes
The cleavage specificity of trypsin and chymotrypsin depend in part on the

absence of water in the active site
presence of a low-barrier hydrogen bond in the active site or specificity pocket
proximity of Ser 195 to the active site or specificity pocket
size, shape, and charge of the active site or specificity pocket

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Enzymes
Enzyme-driven metabolic pathways can be made more efficient by

All of these
concentrating enzymes within specific cellular compartments
fixing enzymes into membranes so that they are adjacent to each other
grouping enzymes into free-floating, multienzyme complexes

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