Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages
infections following dental work due to bacteria entering the bloodstream
bacterial infections
mucosal pathogens

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded
the virus particles with altered (mutant) proteases arise
the drugs that are good inhibitors cannot by synthesized
the drugs interfere with normal digestion

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