Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

infections following dental work due to bacteria entering the bloodstream
bacterial infections
mucosal pathogens
pathogens which can survive inside macrophages

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching
failure of B cells to provide co-stimulation for Th2 activation
activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation

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