Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages
bacterial infections
infections following dental work due to bacteria entering the bloodstream
mucosal pathogens

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation
failure of Th2 cells to provide co-stimulation for B cell isotype switching
failure of Th2 cells to provide co-stimulation for B cell proliferation
activation of B cells by T-independent antigens

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
inserting a gene so that it will function properly
GVHD caused by mature T cells in the transplanted cells
limited life span of more mature hematopoietic cells

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

infected cell processing of virus peptides
macrophage intracellular killing of bacteria
dendritic cell activation to become a mature APC
CTL killing of viruses

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