Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded
the virus particles with altered (mutant) proteases arise
the drugs that are good inhibitors cannot by synthesized
the drugs interfere with normal digestion

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately
come from one of the child's parents
be irradiated to eliminate GVHD
come from a donor that shares some MHC alleles with the recipient

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria
CTL killing of viruses
dendritic cell activation to become a mature APC
infected cell processing of virus peptides

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