Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis
CD8 T cell-mediated cytotoxicity
alternative complement activation.
macrophage activation to vesicular pathogens

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of Th2 cells to provide co-stimulation for B cell isotype switching
activation of B cells by T-independent antigens

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