Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens
IgG synthesis
CD8 T cell-mediated cytotoxicity
alternative complement activation.

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs interfere with normal digestion
the virus particles with altered (mutant) proteases arise
the drugs that are good inhibitors cannot by synthesized
the drugs are rapidly degraded

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses
dendritic cell activation to become a mature APC
macrophage intracellular killing of bacteria
infected cell processing of virus peptides

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching
activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation

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