Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly
GVHD caused by mature T cells in the transplanted cells
transducing genetic material into stem cells
limited life span of more mature hematopoietic cells

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately
come from a donor that shares some MHC alleles with the recipient
be irradiated to eliminate GVHD
come from one of the child's parents

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs interfere with normal digestion
the virus particles with altered (mutant) proteases arise
the drugs that are good inhibitors cannot by synthesized
the drugs are rapidly degraded

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