Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells
limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria
CTL killing of viruses
dendritic cell activation to become a mature APC
infected cell processing of virus peptides

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