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Disease Associated with Immune System

Disease Associated with Immune System
Retinoblastoma is due to a mutation in a

kinase
tumor supressor
viral gene
cyclin

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Disease Associated with Immune System
Specific translocations are associated with

colon cancer
breast cancer
pancreatic cancer
some leukemias

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Disease Associated with Immune System
Combined cellular and humoral immune deficiencies result from lack of all of the following except

HIV infection of CD4+ T cells
transporter of antigen peptides (TAP)
class II MHC
a thymus

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Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis
alternative complement activation.
macrophage activation to vesicular pathogens
CD8 T cell-mediated cytotoxicity

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Disease Associated with Immune System
The HIV virus infects primarily

brain cells
red blood cells
liver cells
cells in the immune system

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Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2
knock-out mouse for a thymus
nude mouse
recombinant mouse for CD3

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