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Disease Associated with Immune System

Disease Associated with Immune System
Retinoblastoma is due to a mutation in a

cyclin
viral gene
tumor supressor
kinase

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Disease Associated with Immune System
Infants are most susceptible to bacterial infection due to low circulating levels of IgG

in utero (before birth)
at 12-24 months of age
at 3-12 months of age
at 0-3 months of age

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Disease Associated with Immune System
Specific translocations are associated with

some leukemias
breast cancer
pancreatic cancer
colon cancer

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Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages
bacterial infections
mucosal pathogens
infections following dental work due to bacteria entering the bloodstream

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Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis
alternative complement activation.
macrophage activation to vesicular pathogens
CD8 T cell-mediated cytotoxicity

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Disease Associated with Immune System
A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Leu or Ileu
His or Pro
Tyr or Phe
Ser or Thr

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