Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus
nude mouse
knock-out mouse for RAG-1 and RAG-2
recombinant mouse for CD3

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs interfere with normal digestion
the drugs are rapidly degraded
the drugs that are good inhibitors cannot by synthesized
the virus particles with altered (mutant) proteases arise

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly
transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

infected cell processing of virus peptides
macrophage intracellular killing of bacteria
dendritic cell activation to become a mature APC
CTL killing of viruses

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