Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus
nude mouse
recombinant mouse for CD3
knock-out mouse for RAG-1 and RAG-2

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
limited life span of more mature hematopoietic cells
GVHD caused by mature T cells in the transplanted cells
inserting a gene so that it will function properly

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