Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus
nude mouse
recombinant mouse for CD3
knock-out mouse for RAG-1 and RAG-2

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses
dendritic cell activation to become a mature APC
macrophage intracellular killing of bacteria
infected cell processing of virus peptides

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching
activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells
limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly

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