Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized
the virus particles with altered (mutant) proteases arise
the drugs interfere with normal digestion
the drugs are rapidly degraded

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria
infected cell processing of virus peptides
CTL killing of viruses
dendritic cell activation to become a mature APC

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