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Disease Associated with Immune System

Disease Associated with Immune System
Specific translocations are associated with

pancreatic cancer
colon cancer
some leukemias
breast cancer

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Disease Associated with Immune System
An autoimmune disease is

AIDS
Mumps
Measles
Lupus

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Disease Associated with Immune System
Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus
transporter of antigen peptides (TAP)
HIV infection of CD4+ T cells
class II MHC

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Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages
bacterial infections
mucosal pathogens
infections following dental work due to bacteria entering the bloodstream

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Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2
nude mouse
recombinant mouse for CD3
knock-out mouse for a thymus

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Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

CD8 T cell-mediated cytotoxicity
macrophage activation to vesicular pathogens
alternative complement activation.
IgG synthesis

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