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Disease Associated with Immune System

Disease Associated with Immune System
Specific translocations are associated with

colon cancer
breast cancer
some leukemias
pancreatic cancer

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Disease Associated with Immune System
Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age
at 3-12 months of age
at 0-3 months of age
in utero (before birth)

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Disease Associated with Immune System
A selective IgA deficiency would be expected to result in problems with

bacterial infections
infections following dental work due to bacteria entering the bloodstream
mucosal pathogens
pathogens which can survive inside macrophages

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Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

recombinant mouse for CD3
nude mouse
knock-out mouse for RAG-1 and RAG-2
knock-out mouse for a thymus

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Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

CD8 T cell-mediated cytotoxicity
macrophage activation to vesicular pathogens
alternative complement activation.
IgG synthesis

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Disease Associated with Immune System
Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus
HIV infection of CD4+ T cells
transporter of antigen peptides (TAP)
class II MHC

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