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Disease Associated with Immune System

Disease Associated with Immune System
Specific translocations are associated with

colon cancer
breast cancer
some leukemias
pancreatic cancer

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Disease Associated with Immune System
Infants are most susceptible to bacterial infection due to low circulating levels of IgG

in utero (before birth)
at 0-3 months of age
at 12-24 months of age
at 3-12 months of age

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Disease Associated with Immune System
The HIV virus infects primarily

brain cells
red blood cells
cells in the immune system
liver cells

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Disease Associated with Immune System
A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr
Leu or Ileu
His or Pro
Tyr or Phe

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Disease Associated with Immune System
If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens
CD8 T cell-mediated cytotoxicity
alternative complement activation.
IgG synthesis

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Disease Associated with Immune System
DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

recombinant mouse for CD3
knock-out mouse for a thymus
nude mouse
knock-out mouse for RAG-1 and RAG-2

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