Disease Associated with Immune System
Combined cellular and humoral immune deficiencies result from lack of all of the following except

class II MHC
HIV infection of CD4+ T cells
transporter of antigen peptides (TAP)
a thymus

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD
contain mature T cells that can begin making immune responses immediately
come from one of the child's parents
come from a donor that shares some MHC alleles with the recipient

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Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of Th2 cells to provide co-stimulation for B cell isotype switching
failure of B cells to provide co-stimulation for Th2 activation

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized
the drugs are rapidly degraded
the virus particles with altered (mutant) proteases arise
the drugs interfere with normal digestion

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