Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells
limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly
transducing genetic material into stem cells

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses
infected cell processing of virus peptides
dendritic cell activation to become a mature APC
macrophage intracellular killing of bacteria

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