Disease Associated with Immune System
Bone marrow given to an infant with SCID must

come from one of the child's parents
come from a donor that shares some MHC alleles with the recipient
be irradiated to eliminate GVHD
contain mature T cells that can begin making immune responses immediately

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC
infected cell processing of virus peptides
macrophage intracellular killing of bacteria
CTL killing of viruses

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells
inserting a gene so that it will function properly
transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells

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