Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells
transducing genetic material into stem cells
inserting a gene so that it will function properly
limited life span of more mature hematopoietic cells

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately
come from a donor that shares some MHC alleles with the recipient
be irradiated to eliminate GVHD
come from one of the child's parents

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs interfere with normal digestion
the drugs are rapidly degraded
the drugs that are good inhibitors cannot by synthesized
the virus particles with altered (mutant) proteases arise

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC
infected cell processing of virus peptides
CTL killing of viruses
macrophage intracellular killing of bacteria

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