Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
GVHD caused by mature T cells in the transplanted cells
inserting a gene so that it will function properly
limited life span of more mature hematopoietic cells

ANSWER DOWNLOAD EXAMIANS APP

Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

infected cell processing of virus peptides
CTL killing of viruses
macrophage intracellular killing of bacteria
dendritic cell activation to become a mature APC

ANSWER DOWNLOAD EXAMIANS APP

Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation
failure of Th2 cells to provide co-stimulation for B cell isotype switching

ANSWER DOWNLOAD EXAMIANS APP

Disease Associated with Immune System
Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately
come from one of the child's parents
be irradiated to eliminate GVHD
come from a donor that shares some MHC alleles with the recipient

ANSWER DOWNLOAD EXAMIANS APP