Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
limited life span of more mature hematopoietic cells
GVHD caused by mature T cells in the transplanted cells
inserting a gene so that it will function properly

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded
the virus particles with altered (mutant) proteases arise
the drugs that are good inhibitors cannot by synthesized
the drugs interfere with normal digestion

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