Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation
activation of B cells by T-independent antigens

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC
infected cell processing of virus peptides
macrophage intracellular killing of bacteria
CTL killing of viruses

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately
come from a donor that shares some MHC alleles with the recipient
be irradiated to eliminate GVHD
come from one of the child's parents

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