Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of B cells to provide co-stimulation for Th2 activation
activation of B cells by T-independent antigens
failure of Th2 cells to provide co-stimulation for B cell isotype switching

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Disease Associated with Immune System
Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses
infected cell processing of virus peptides
macrophage intracellular killing of bacteria
dendritic cell activation to become a mature APC

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Disease Associated with Immune System
To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized
the drugs interfere with normal digestion
the drugs are rapidly degraded
the virus particles with altered (mutant) proteases arise

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD
come from a donor that shares some MHC alleles with the recipient
contain mature T cells that can begin making immune responses immediately
come from one of the child's parents

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