Disease Associated with Immune System
X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation
failure of Th2 cells to provide co-stimulation for B cell proliferation
failure of Th2 cells to provide co-stimulation for B cell isotype switching
activation of B cells by T-independent antigens

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Disease Associated with Immune System
Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells
limited life span of more mature hematopoietic cells
GVHD caused by mature T cells in the transplanted cells
inserting a gene so that it will function properly

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Disease Associated with Immune System
Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD
contain mature T cells that can begin making immune responses immediately
come from a donor that shares some MHC alleles with the recipient
come from one of the child's parents

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