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Monoclonal Antibodies

Monoclonal Antibodies
Which type of cell actually secrets antibodies?

plasma cells
T cells
dendritic cells
macrophages

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

Transfection with tumor derived DNA
Hybridization with a suitable lymphoid tumor cell
All of these
Transformation following infection by Epstein-Barr virus (EB V)

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Monoclonal Antibodies
Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

absence of human immune response against murine proteins (HAMA) response
poor recognition of immunoglobulin, Ig constant regions
presence of HAMA response
All of these

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Monoclonal Antibodies
In human B cells and T cells are matured in the

bursa and thymus respectively
none of these
lymph nodes and spleen respectively
bone marrow and thymus respectively

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Monoclonal Antibodies
Small simple molecules are

rich antigens
poor antigens
heterophilic antigens
moderate antigens

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Monoclonal Antibodies
In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

natural killer cell
lymphoblast
myeloma
hybridoma

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