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Monoclonal Antibodies

Monoclonal Antibodies
TC cells are important in controlling

autoimmunity
allergy
all of these
virus infections

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Monoclonal Antibodies
An example of mosaic antigen is

virus
a hapten
protein
bacteria

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

Hybridization with a suitable lymphoid tumor cell
Transformation following infection by Epstein-Barr virus (EB V)
Transfection with tumor derived DNA
All of these

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Monoclonal Antibodies
In human B cells and T cells are matured in the

bone marrow and thymus respectively
none of these
lymph nodes and spleen respectively
bursa and thymus respectively

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Monoclonal Antibodies
Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

presence of HAMA response
absence of human immune response against murine proteins (HAMA) response
poor recognition of immunoglobulin, Ig constant regions
All of these

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Monoclonal Antibodies
The EBV-hybridoma technique

gives much higher hybridization frequencies
facilitates the proliferation of antigen specific B cells
All of these
immortalizes the donor Bcells

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