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Monoclonal Antibodies

Monoclonal Antibodies
The primary B cell receptor is

IgD
IgA
IgE
IgG

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Monoclonal Antibodies
In human B cells and T cells are matured in the

lymph nodes and spleen respectively
bursa and thymus respectively
none of these
bone marrow and thymus respectively

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Monoclonal Antibodies
Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

IgA
IgE
Ig MAbs
IgG

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Monoclonal Antibodies
The Ig locus is about

l/2nd of all hybridomas
1/4th of all hybridomas
2/3rd of all hybridomas
l/3rd of all hybridomas

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Monoclonal Antibodies
The EBV-hybridoma technique

immortalizes the donor Bcells
All of these
facilitates the proliferation of antigen specific B cells
gives much higher hybridization frequencies

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

All of these
Hybridization with a suitable lymphoid tumor cell
Transformation following infection by Epstein-Barr virus (EB V)
Transfection with tumor derived DNA

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