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Monoclonal Antibodies

Monoclonal Antibodies
An example of mosaic antigen is

bacteria
protein
a hapten
virus

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Monoclonal Antibodies
The Ig locus is about

2/3rd of all hybridomas
l/2nd of all hybridomas
1/4th of all hybridomas
l/3rd of all hybridomas

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Monoclonal Antibodies
Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

All of these
absence of human immune response against murine proteins (HAMA) response
poor recognition of immunoglobulin, Ig constant regions
presence of HAMA response

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Monoclonal Antibodies
It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

low frequencies
high frequencies
at no frequency
moderate frequencies

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

Transformation following infection by Epstein-Barr virus (EB V)
Hybridization with a suitable lymphoid tumor cell
Transfection with tumor derived DNA
All of these

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Monoclonal Antibodies
In human B cells and T cells are matured in the

bursa and thymus respectively
none of these
bone marrow and thymus respectively
lymph nodes and spleen respectively

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