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Monoclonal Antibodies

Monoclonal Antibodies
An example of mosaic antigen is

virus
a hapten
protein
bacteria

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Monoclonal Antibodies
Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

IgA
IgE
IgG
Ig MAbs

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Monoclonal Antibodies
T cells are the source of

lymphotoxin
interferon
all of these
interleukin

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Monoclonal Antibodies
The cross linkage of antigens by antibodies is known as

a cross reaction
agglutination
complement fixation
all of these

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

All of these
Transformation following infection by Epstein-Barr virus (EB V)
Transfection with tumor derived DNA
Hybridization with a suitable lymphoid tumor cell

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Monoclonal Antibodies
The EBV-hybridoma technique

facilitates the proliferation of antigen specific B cells
immortalizes the donor Bcells
gives much higher hybridization frequencies
All of these

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