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Monoclonal Antibodies

Monoclonal Antibodies
T cells are the source of

all of these
interferon
lymphotoxin
interleukin

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Monoclonal Antibodies
Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

absence of human immune response against murine proteins (HAMA) response
poor recognition of immunoglobulin, Ig constant regions
All of these
presence of HAMA response

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Monoclonal Antibodies
An example of mosaic antigen is

a hapten
protein
virus
bacteria

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Monoclonal Antibodies
The antigen-specific lymphocytes can be immortalized by which of the following method?

All of these
Transformation following infection by Epstein-Barr virus (EB V)
Transfection with tumor derived DNA
Hybridization with a suitable lymphoid tumor cell

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Monoclonal Antibodies
The EBV-hybridoma technique

gives much higher hybridization frequencies
facilitates the proliferation of antigen specific B cells
immortalizes the donor Bcells
All of these

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Monoclonal Antibodies
It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at

high frequencies
moderate frequencies
low frequencies
at no frequency

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