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Structure and Properties of Peptides

Structure and Properties of Peptides
Which of the following is an example of tertiary structure in a protein?

A multimeric protein
A globular domain
An a-helix
A P-pleated sheet

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Structure and Properties of Peptides
The resonance structures that can be drawn for the peptide bond indicate that the peptide bond

both (a) and (b)
is stronger than an ordinary single bond
has partial double bond character
is still not completely understood

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Structure and Properties of Peptides
An oil drop with a polar coat is a metaphor referring to the three dimensional structure of

silk protein
collagen
globular proteins
fibrous proteins

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Lysozyme
Pancreatic DNase
Myoglobin
Pancreatic ribonuclease

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

have Y = F = 180°
do not occur in nature
are equivalent to the (3-sheet structure
also have a cis geometry in their peptide bonds

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
not present at Phe residues
roughly parallel to the helix axis
more numerous than Vander Waals interactions

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