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Structure and Properties of Peptides

Structure and Properties of Peptides
Which of the following is an example of tertiary structure in a protein?

A globular domain
A multimeric protein
A P-pleated sheet
An a-helix

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Structure and Properties of Peptides
What is the effect of a decrease in pH on hemoglobin oxygen affinity?

Increase affinity in muscle cell otherwise decrease
Decrease in oxygen affinity
Increase in oxygen affinity
No effect on oxygen affinity

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Structure and Properties of Peptides
The same peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala. was digested with chymotrypsin to produce

Val-Lys-Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala.
Val-Lys + Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala.

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Structure and Properties of Peptides
The peptide bond in proteins is

is planar because of steric hinderance
usually cis unless proline is the next amino acid
usually trans unless proline is the next amino acid
only found between proline residues

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Lysozyme
Pancreatic DNase
Myoglobin
Pancreatic ribonuclease

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
roughly parallel to the helix axis
not present at Phe residues
more numerous than Vander Waals interactions

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