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Structure and Properties of Peptides

Structure and Properties of Peptides
Disulfide bonds most often stabilize the native structure of

extracellular proteins
hydrophobic proteins
intracellular proteins
dimeric proteins

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
roughly parallel to the helix axis
not present at Phe residues
more numerous than Vander Waals interactions

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Structure and Properties of Peptides
The heme is held in place by a bond between

the Fe2+ and histidine
the Fe2+ and cysteine
the Fe3+ and cysteine
the Fe3+ and histidine

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Structure and Properties of Peptides
The oxygen binding curves of hemoglobin and myoglobin

are a consequence of the quaternary structure of hemoglobin
both (a) and (b)
allow maximum transfer of oxygen to the tissues
are identical

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Structure and Properties of Peptides
The different orders of protein structure are determined by all of the following bond types except

phospho-diester bonds
peptide bonds
disulfide bridges
hydrogen bonds

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Structure and Properties of Peptides
What is the effect of a decrease in pH on hemoglobin oxygen affinity?

Increase affinity in muscle cell otherwise decrease
Decrease in oxygen affinity
Increase in oxygen affinity
No effect on oxygen affinity

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