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Structure and Properties of Peptides

Structure and Properties of Peptides
Disulfide bonds most often stabilize the native structure of

intracellular proteins
extracellular proteins
dimeric proteins
hydrophobic proteins

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Structure and Properties of Peptides
The peptide bond in proteins is

is planar because of steric hinderance
usually cis unless proline is the next amino acid
usually trans unless proline is the next amino acid
only found between proline residues

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Structure and Properties of Peptides
The nature of peptide bond can be best explained as

truly double bond
Hydrogen bond
partial double bond
Van der waals force

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

also have a cis geometry in their peptide bonds
are equivalent to the (3-sheet structure
have Y = F = 180°
do not occur in nature

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Structure and Properties of Peptides
In the β-pleated sheet

All of these
hydrogen bonds are formed between the peptide bonds
adjacent polypeptide chains can either be parallel or antiparallel
the polypeptide chain is fully extended

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Structure and Properties of Peptides
If the F and Y angles of each peptide unit in a protein are known, which of the following may also be determined?

Thermodynamic stability
Complete quaternary structure
Complete secondary structure
Complete tertiary structure

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