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Structure and Properties of Peptides

Structure and Properties of Peptides
Disulfide bonds most often stabilize the native structure of

dimeric proteins
hydrophobic proteins
extracellular proteins
intracellular proteins

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Structure and Properties of Peptides
The peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala, was digested with cyanogen bromide (CNBr) to produce:

Val-Lys-Glu-Met + Ser-Trp-Arg-Ala
Val-Lys + Glu-Met-Ser + Trp-Arg-Ala
Val-Lys-Glu + Met-Ser-Trp-Arg-Ala
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
more numerous than Vander Waals interactions
roughly parallel to the helix axis
not present at Phe residues

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Structure and Properties of Peptides
In β-pleated sheet structures neighbouring

neighboring chains are hydrogen bonded
neighboring chains are connected by a-helices
neighboring residues are hydrogen bonded
chains lie in a flat plane

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Structure and Properties of Peptides
Which hemoglobin chain replaces the beta chain in embryonic hemoglobulin?

Gamma
Alfa
Epsilon
Delta

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

are equivalent to the (3-sheet structure
do not occur in nature
also have a cis geometry in their peptide bonds
have Y = F = 180°

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