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Structure and Properties of Peptides

Structure and Properties of Peptides
Disulfide bonds most often stabilize the native structure of

extracellular proteins
hydrophobic proteins
dimeric proteins
intracellular proteins

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Structure and Properties of Peptides
The same peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala. was digested with chymotrypsin to produce

Val-Lys + Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala.
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser + Trp-Arg-Ala.

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Structure and Properties of Peptides
The peptide bond in proteins is

is planar because of steric hinderance
usually trans unless proline is the next amino acid
usually cis unless proline is the next amino acid
only found between proline residues

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Structure and Properties of Peptides
An oil drop with a polar coat is a metaphor referring to the three dimensional structure of

collagen
fibrous proteins
silk protein
globular proteins

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Structure and Properties of Peptides
In the β-pleated sheet

hydrogen bonds are formed between the peptide bonds
adjacent polypeptide chains can either be parallel or antiparallel
the polypeptide chain is fully extended
All of these

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Structure and Properties of Peptides
The resonance structures that can be drawn for the peptide bond indicate that the peptide bond

has partial double bond character
is still not completely understood
is stronger than an ordinary single bond
both (a) and (b)

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