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Structure and Properties of Peptides

Structure and Properties of Peptides
Which of the three subunits of the G proteins binds GDP and GTP?

Beta
Gamma
Alpha
Delta

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

do not occur in nature
are equivalent to the (3-sheet structure
also have a cis geometry in their peptide bonds
have Y = F = 180°

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Pancreatic ribonuclease
Myoglobin
Lysozyme
Pancreatic DNase

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

more numerous than Vander Waals interactions
not present at Phe residues
roughly parallel to the helix axis
analogous to the steps in a spiral staircase

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Structure and Properties of Peptides
The peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala, was digested with cyanogen bromide (CNBr) to produce:

Val-Lys + Glu-Met-Ser + Trp-Arg-Ala
Val-Lys-Glu + Met-Ser-Trp-Arg-Ala
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala

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Structure and Properties of Peptides
The different orders of protein structure are determined by all of the following bond types except

peptide bonds
hydrogen bonds
phospho-diester bonds
disulfide bridges

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