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Structure and Properties of Peptides

Structure and Properties of Peptides
The major element of secondary structure in myoglobin and hemoglobin is

the reverse turn
All of these
the P-strand
the a-helix

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Structure and Properties of Peptides
Heme is the binding pocket of myoglobin and hemoglobin and is composed of

hydrophobic residues
negatively charged residues
positively charged residues
polar residues

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Structure and Properties of Peptides
In β-pleated sheet structures neighbouring

neighboring residues are hydrogen bonded
neighboring chains are connected by a-helices
chains lie in a flat plane
neighboring chains are hydrogen bonded

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Structure and Properties of Peptides
The same peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala. was digested with chymotrypsin to produce

Val-Lys + Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala.
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala.

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

are equivalent to the (3-sheet structure
also have a cis geometry in their peptide bonds
do not occur in nature
have Y = F = 180°

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Structure and Properties of Peptides
The resonance structures that can be drawn for the peptide bond indicate that the peptide bond

is stronger than an ordinary single bond
both (a) and (b)
is still not completely understood
has partial double bond character

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