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Structure and Properties of Peptides

Structure and Properties of Peptides
An oil drop with a polar coat is a metaphor referring to the three dimensional structure of

silk protein
fibrous proteins
collagen
globular proteins

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Structure and Properties of Peptides
The same peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala. was digested with chymotrypsin to produce

Val-Lys-Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala.
Val-Lys + Glu-Met-Ser + Trp-Arg-Ala.

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

do not occur in nature
are equivalent to the (3-sheet structure
have Y = F = 180°
also have a cis geometry in their peptide bonds

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Structure and Properties of Peptides
The oxygen binding curves of hemoglobin and myoglobin

both (a) and (b)
are a consequence of the quaternary structure of hemoglobin
allow maximum transfer of oxygen to the tissues
are identical

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Lysozyme
Pancreatic ribonuclease
Myoglobin
Pancreatic DNase

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Structure and Properties of Peptides
Disulfide bonds most often stabilize the native structure of

hydrophobic proteins
extracellular proteins
intracellular proteins
dimeric proteins

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