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Structure and Properties of Peptides

Structure and Properties of Peptides
An oil drop with a polar coat is a metaphor referring to the three dimensional structure of

collagen
silk protein
fibrous proteins
globular proteins

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Structure and Properties of Peptides
The major element of secondary structure in myoglobin and hemoglobin is

All of these
the P-strand
the a-helix
the reverse turn

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Structure and Properties of Peptides
The oxygen binding curves of hemoglobin and myoglobin

allow maximum transfer of oxygen to the tissues
are a consequence of the quaternary structure of hemoglobin
are identical
both (a) and (b)

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

are equivalent to the (3-sheet structure
have Y = F = 180°
do not occur in nature
also have a cis geometry in their peptide bonds

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Structure and Properties of Peptides
If the F and Y angles of each peptide unit in a protein are known, which of the following may also be determined?

Thermodynamic stability
Complete tertiary structure
Complete secondary structure
Complete quaternary structure

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

more numerous than Vander Waals interactions
not present at Phe residues
analogous to the steps in a spiral staircase
roughly parallel to the helix axis

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