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Structure and Properties of Peptides

Structure and Properties of Peptides
An oil drop with a polar coat is a metaphor referring to the three dimensional structure of

globular proteins
collagen
silk protein
fibrous proteins

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Structure and Properties of Peptides
The oxygen in hemoglobin and myoglobin is bound to

the nitrogen atoms on the heme
lysine residues in the protein
histidine residues in the protein
the iron atom in the heme group

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

have Y = F = 180°
are equivalent to the (3-sheet structure
do not occur in nature
also have a cis geometry in their peptide bonds

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
not present at Phe residues
roughly parallel to the helix axis
more numerous than Vander Waals interactions

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Structure and Properties of Peptides
Which of the following is an example of tertiary structure in a protein?

A multimeric protein
A globular domain
An a-helix
A P-pleated sheet

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Structure and Properties of Peptides
When pO2 = Kd of myoglobin, the fractional saturation (YO2) is about

1.7
0.1
0.9
0.5

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