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Structure and Properties of Peptides

Structure and Properties of Peptides
The heme is held in place by a bond between

the Fe3+ and histidine
the Fe2+ and histidine
the Fe3+ and cysteine
the Fe2+ and cysteine

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

more numerous than Vander Waals interactions
roughly parallel to the helix axis
not present at Phe residues
analogous to the steps in a spiral staircase

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Structure and Properties of Peptides
The same peptide, Val-Lys-Glu-Met-Ser-Trp-Arg-Ala. was digested with chymotrypsin to produce

Val-Lys-Glu-Met-Ser + Trp-Arg-Ala.
Val-Lys-Glu-Met-Ser-Trp + Arg-Ala.
Val-Lys-Glu-Met + Ser-Trp-Arg-Ala.
Val-Lys + Glu-Met-Ser + Trp-Arg-Ala.

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Structure and Properties of Peptides
The resonance structures that can be drawn for the peptide bond indicate that the peptide bond

both (a) and (b)
is stronger than an ordinary single bond
is still not completely understood
has partial double bond character

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Structure and Properties of Peptides
The oxygen binding curves of hemoglobin and myoglobin

are identical
both (a) and (b)
are a consequence of the quaternary structure of hemoglobin
allow maximum transfer of oxygen to the tissues

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Pancreatic DNase
Lysozyme
Myoglobin
Pancreatic ribonuclease

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