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Structure and Properties of Peptides

Structure and Properties of Peptides
The heme is held in place by a bond between

the Fe3+ and histidine
the Fe2+ and histidine
the Fe2+ and cysteine
the Fe3+ and cysteine

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Structure and Properties of Peptides
In the β-pleated sheet

All of these
the polypeptide chain is fully extended
adjacent polypeptide chains can either be parallel or antiparallel
hydrogen bonds are formed between the peptide bonds

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Structure and Properties of Peptides
In β-pleated sheet structures neighbouring

neighboring residues are hydrogen bonded
chains lie in a flat plane
neighboring chains are hydrogen bonded
neighboring chains are connected by a-helices

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Structure and Properties of Peptides
What was the first protein whose complete tertiary structure was determined?

Myoglobin
Pancreatic ribonuclease
Lysozyme
Pancreatic DNase

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

analogous to the steps in a spiral staircase
roughly parallel to the helix axis
not present at Phe residues
more numerous than Vander Waals interactions

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

are equivalent to the (3-sheet structure
also have a cis geometry in their peptide bonds
do not occur in nature
have Y = F = 180°

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