Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

mutagenized copies of a gene
short sequences that will hybridize only to a specific base sequence
PCR-amplified variable numbers of tandem repeats (VNTRs)
copies of the gene with an altered sequence so that a restriction site is inserted

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Recombinant DNA Technology
An example of a restriction fragment length polymorphism is

cystic fibrosis results from a three base deletion in most cases but in other cases, other mutations are involved
All of these
different length fragments of DNA resulting from loss or gain of a restriction site
an Eco RI cuts DNA at a different sequence than Hind III

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Recombinant DNA Technology
Isoschizomers recognize

different recognition site and different recognition sequence
same recognition site and recognition sequence
same recognition site and different recognition sequence
same recognition sequence but different recognition site

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Recombinant DNA Technology
Which of the following is correct in terms of determination of location of genetic traits?

None of these
Restriction sites allow DNAs to be digested
Known protein coding sequences are too far apart to allow linkage determination for most new genes
Protein-coding genes are always associated with a restriction pattern

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