Cell Signalling and Transduction
The binding of ligands to many G-proteins linked receptors leads to shortlived

increase in the concentration of certain extracellular signaling molecules called first messenger
decrease in the concentration of certain extracellular signaling molecules called first messenger
increase in the concentration of certain intracellular signaling molecules called second messenger
decrease in the concentration of certain intracellular signaling molecules called second messenger

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Cell Signalling and Transduction
If a disease of the blood vessels caused the endothelial cells of the vessel to die, what effect would that have on the cellular activities associated with vasodilation?

All of these
It would be more difficult to increase blood flow and reduce blood pressure
Nitric oxide would no longer be produced
Smooth muscle cells could not be made to relax

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