Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

PCR-amplified variable numbers of tandem repeats (VNTRs)
short sequences that will hybridize only to a specific base sequence
mutagenized copies of a gene
copies of the gene with an altered sequence so that a restriction site is inserted

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Recombinant DNA Technology
Which of the following is correct in terms of determination of location of genetic traits?

Protein-coding genes are always associated with a restriction pattern
None of these
Known protein coding sequences are too far apart to allow linkage determination for most new genes
Restriction sites allow DNAs to be digested

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